Representative Publications
Approximately 200 publications have arisen from work at the Centre over the last five years. The following are representative:
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Simonelli L, Beltramello M, Yudina Z, Macagno A, Calzolai L, Varani L (2010). Rapid Structural Characterization of Human Antibody-Antigen Complexes through Experimentally Validated Computational Docking. J Mol Biol 396, 1491-1507.
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Pancevac C, Goldstone DC, Ramos A, Taylor IA (2010) Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors. Nucleic Acids Research Advance pp. DOI 10.1093/nar/gkq1002.
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Jarvis A, Allerston CK, Jia HY, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng LL, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL (2010). Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction. J Med Chem 53, 2215-2226.
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Hands-Taylor KLD, Martino L, Tata R, Babon JJ, Bui TT, Drake AF, Beavil RL, Pruijn GJM, Brown PR, Conte MR (2010) Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA. Nucleic Acids Res. pp. gkq141.
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Diaz-Moreno I, Hollingworth D, Kelly G, Martin S, Garcia-Mayoral M, Briata P, Gherzi R, Ramos A (2010) Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research Advance pp. doi10.1093/nar/gkq1216.
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Adrover M, Pauwels K, Pringent S, de Chiara C, Xu Z, Chapuis C, Pastore A, Rezaei H (2010) Prion fibrillization is mediated by a native structural element which comprises the helices H2 and H3. J. of Biol. Chem. PMID: 20375014
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Young AM, Man Ho S, Abou Neel EA, Ahmed I, Barralet JE, Knowles JC, Nazhat SN (2009). Chemical characterization of a degradable polymeric bone adhesive containing hydrolysable fillers and interpretation of anomalous mechanical properties. Acta Biomater 5, 2072-2083.
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Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG (2009). The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459, 1010-U1144.
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Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ (2009). Solution Structure and Dynamics of ERp18, a Small Endoplasmic Reticulum Resident Oxidoreductase. Biochemistry-Us 48, 4596-4606.
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Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ (2009). An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis. Science Signalling 2, ra12-.
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Martino L, He YZ, Hands-Taylor KLD, Valentine ER, Kelly G, Giancola C, Conte MR (2009). The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity. Febs Journal 276, 4529-4544.
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Diaz-Moreno I, Hollingworth D, Frenkiel TA, Kelly G, Martin S, Howell S, Garcia-Mayoral M, Gherzi R, Briata P, Ramos A (2009). Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. Nat Struct Mol Biol 16, 238-246.
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Cabrita LD, Hsu STD, Launay H, Dobson CM, Christodoulou J (2009). Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. P Natl Acad Sci USA 106, 22239-22244.
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Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, Bonomi F, Pastore A (2009). Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS. Nat Struct Mol Biol 16, 390-396.
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Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE (2008). Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design. Proteins 73, 929-940.
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Scheschonka A, Findlow S, Schemm R, El Far O, Caldwell JH, Crump MP, Holden-Dye K, O'Connor V, Betz H, Werner JM (2008). Structural determinants of calmodulin binding to the intracellular c-terminal domain of the metabotropic glutamate receptor 7A. J Biol Chem 283, 5577-5588.
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Nadal RC, Rigby SEJ, Viles JH (2008). Amyloid beta-Cu2+ Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2 Catalytically but Quench Hydroxyl Radicals. Biochemistry-Us 47, 11653-11664.
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Garcia-Mayoral MF, Diaz-Moreno I, Hollingworth D, Ramos A (2008). The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets. Nucleic Acids Res 36, 5290-5296.
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Schiodt CB, Veitch NC, Welinder KG (2007). Roles of distal arginine in activity and stability of Coprinus cinereus peroxidase elucidated by kinetic and NMR analysis of the Arg51Gln, -Asn, -Leu, and -Lys mutants. J Inorg Biochem 101, 336-347.
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Munasinghe VR, Corrie JE, Kelly G, Martin SR (2007). Fluorescent ligands for the hemagglutinin of influenza A: synthesis and ligand binding assays. Bioconjug Chem 18, 231-237.
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Liu Y, Feizi T, Campanero-Rhodes MA, Childs RA, Zhang Y, Mulloy B, Evans PG, Osborn HMI, Otto D, Crocker PR, Chai W (2007). Neoglycolipid Probes Prepared via Oxime Ligation for Microarray Analysis of Oligosaccharide-Protein Interactions. Chemistry and Biology 14, 847-859.
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Garcia-Mayoral MF, Hollingworth D, Masino L, Diaz-Moreno I, Kelly G, Gherzi R, Chou CF, Chen CY, Ramos A (2007). The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation. Structure 15, 485-498.
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Beuth B, Garcia-Mayoral MF, Taylor IA, Ramos A (2007). Scaffold-independent analysis of RNA-protein interactions: the Nova-1 KH3-RNA complex. J Am Chem Soc 129, 10205-10210.
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Bayliss R, Harris R, Coutte L, Monier A, Fronzes R, Christie PJ, Driscoll PC, Waksman G (2007). NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system. P Natl Acad Sci USA 104, 1673-1678.
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Golovanov AP, Hautbergue GM, Tintaru AM, Lian LY, Wilson SA (2006). The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. Rna 12, 1933-1948.