Representative Publications

Approximately 200 publications have arisen from work at the Centre over the last five years. The following are representative:

  • Posner, M.G., Upadhyay, A., Crennell, S.J., Watson, A.J., Dorus, S., Danson, M.J. and Bagby, S. (2013). Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation. Biochem J. 449, 415-425

  • Adrover, M., Martorell, G., Martin, S.R., Urosev, D., Konarev, P.V., Svergun, D.I., Daura, X., Temussi, P. and Pastore, A. (2012). The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1. J Mol Biol 417(5), 413-24.

  • Cavaliere, P., Torrent, J., Prigent, S., Granata, V., Pauwels, K., Pastore, A., Rezaei, H. and Zagari, A. (2012). Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein. Biochim Biophys Acta 1832(1), 20-28.

  • Chan, K.K. and Ramesh, V. (2012). Conserved RNA motifs of EMCV IRES as potential building blocks to design RNA nanostructures. Chem Commun (Camb) 48(94), 11573-5.

  • Gu, S., Kelly, G., Wang, X., Frenkiel, T., Shevchik, V.E. and Pickersgill, R.W. (2012). Solution structure of homology region (HR) domain of type II secretion system. J Biol Chem 287(12), 9072-80.

  • Martino, L., Pennell, S., Kelly, G., Bui, T.T., Kotik-Kogan, O., Smerdon, S.J., Drake, A.F., Curry, S. and Conte, M.R. (2012). Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nucleic Acids Res 40(3), 1381-94.

  • Nicastro G, Garcia-Mayoral MF, Hollingworth D, Kelly G, Martin SR, Briata P, Gherzi R, Ramos A. (2012). Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis.  Nat Struct Mol Biol. 19(12),1282-6. doi: 10.1038/nsmb.2427. 

  • Pauwels, K., Williams, T.L., Morris, K.L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L.C. and Broersen, K. (2012). Structural basis for increased toxicity of pathological abeta42:abeta40 ratios in Alzheimer disease. J Biol Chem 287(8), 5650-60.

  • Pedreno, S., Pisco, J.P., Larrouy-Maumus, G., Kelly, G. and de Carvalho, L.P. (2012). Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry 51(40), 8027-38.

  • Sanfelice, D., Adrover, M., Martorell, G., Pastore, A. and Temussi, P.A. (2012). Crowding versus molecular seeding: NMR studies of protein aggregation in hen egg white. J Phys Condens Matter 24(24), 244107.

  • Younan, N.D., Nadal, R.C., Davies, P., Brown, D.R. and Viles, J.H. (2012). Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway. J Biol Chem 287(34), 28263-75.

  • Goldstone, D.C., Ennis-Adeniran, V., Hedden, J.J., Groom, H.C., Rice, G.I., Christodoulou, E., Walker, P.A., Kelly, G., Haire, L.F., Yap, M.W., de Carvalho, L.P., Stoye, J.P., Crow, Y.J., Taylor, I.A. and Webb, M. (2011). HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480(7377), 379-82.

  • Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP. (2011). Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell 146(3), 435-47. doi: 10.1016/j.cell.2011.06.040. PMID: 21816278

  • Zhao, X., Olsen, I., Pratten, J., Knowles, J.C. and Young, A.M. (2011).  Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: setting, degradation and drug release considerations.  Journal of Materials Science-Materials in Medicine 22(9), 1993-2004.

  • Simonelli L, Beltramello M, Yudina Z, Macagno A, Calzolai L, Varani L (2010).  Rapid Structural Characterization of Human Antibody-Antigen Complexes through Experimentally Validated Computational Docking.  J Mol Biol 396, 1491-1507.

  • Cukier CD, Hollingworth D, Martin SR, Kelly G, Diaz-Moreno I, Ramos A. (2010). Molecular basis of FIR-mediated c-myc transcriptional control. Nat Struct Mol Biol. 17(9), 1058-64. doi: 10.1038/nsmb.1883. 

  • Esposito D, Sankar A, Morgner N, Robinson CV, Rittinger K, Driscoll PC. (2010)  Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus. Structure. 18, 1378-90. doi: 10.1016/j.str.2010.08.006.
    PMID: 20947025

  • Jarvis A, Allerston CK, Jia HY, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng LL, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL (2010).  Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction.  J Med Chem 53, 2215-2226.

  • Hands-Taylor KLD, Martino L, Tata R, Babon JJ, Bui TT, Drake AF, Beavil RL, Pruijn GJM, Brown PR, Conte MR (2010) Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA. Nucleic Acids Res. pp. gkq141.

  • Diaz-Moreno I, Hollingworth D, Kelly G, Martin S, Garcia-Mayoral M, Briata P, Gherzi R, Ramos A (2010) Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research Advance pp. doi10.1093/nar/gkq1216.

  • Adrover M, Pauwels K, Pringent S, de Chiara C, Xu Z, Chapuis C, Pastore A, Rezaei H (2010) Prion fibrillization is mediated by a native structural element which comprises the helices H2 and H3. J. Biol. Chem. PMID: 20375014

  • Young AM, Man Ho S, Abou Neel EA, Ahmed I, Barralet JE, Knowles JC, Nazhat SN (2009).  Chemical characterization of a degradable polymeric bone adhesive containing hydrolysable fillers and interpretation of anomalous mechanical properties.  Acta Biomater 5, 2072-2083.

  • Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG (2009).  The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.  Nature 459, 1010-U1144.

  • Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ (2009).  Solution Structure and Dynamics of ERp18, a Small Endoplasmic Reticulum Resident Oxidoreductase.  Biochemistry-Us 48, 4596-4606.

  • Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ (2009).  An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis.  Science Signalling 2, ra12-.

  • Martino L, He YZ, Hands-Taylor KLD, Valentine ER, Kelly G, Giancola C, Conte MR (2009).  The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity.  Febs Journal 276, 4529-4544.

  • Diaz-Moreno I, Hollingworth D, Frenkiel TA, Kelly G, Martin S, Howell S, Garcia-Mayoral M, Gherzi R, Briata P, Ramos A (2009).  Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.  Nat Struct Mol Biol 16, 238-246.

  • Cabrita LD, Hsu STD, Launay H, Dobson CM, Christodoulou J (2009).  Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.  P Natl Acad Sci USA 106, 22239-22244.

  • Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, Bonomi F, Pastore A (2009).  Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.  Nat Struct Mol Biol 16, 390-396.

  • Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE (2008).  Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design.  Proteins 73, 929-940.

  • Scheschonka A, Findlow S, Schemm R, El Far O, Caldwell JH, Crump MP, Holden-Dye K, O'Connor V, Betz H, Werner JM (2008).  Structural determinants of calmodulin binding to the intracellular c-terminal domain of the metabotropic glutamate receptor 7A.  J Biol Chem 283, 5577-5588.

  • Schiodt CB, Veitch NC, Welinder KG (2007).  Roles of distal arginine in activity and stability of Coprinus cinereus peroxidase elucidated by kinetic and NMR analysis of the Arg51Gln, -Asn, -Leu, and -Lys mutants.  J Inorg Biochem 101, 336-347.

  • Munasinghe VR, Corrie JE, Kelly G, Martin SR (2007).  Fluorescent ligands for the hemagglutinin of influenza A: synthesis and ligand binding assays.  Bioconjug Chem 18, 231-237.

  • Liu Y, Feizi T, Campanero-Rhodes MA, Childs RA, Zhang Y, Mulloy B, Evans PG, Osborn HMI, Otto D, Crocker PR, Chai W (2007).  Neoglycolipid Probes Prepared via Oxime Ligation for Microarray Analysis of Oligosaccharide-Protein Interactions.  Chemistry and Biology 14, 847-859.

  • Beuth B, Garcia-Mayoral MF, Taylor IA, Ramos A (2007).  Scaffold-independent analysis of RNA-protein interactions: the Nova-1 KH3-RNA complex.  J Am Chem Soc 129, 10205-10210.

 
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